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Summary of Chemistry doctoral thesis: Study on chemical constituents and biological activities of several Antidesma species growing in Vietnam

The objectives of the thesis: Study on chemical constituents of three Antidesma species including A. acidum, A. ghaesembilla, and A. hainanensis growing in Vietnam; evaluation of biological activities of isolated metabolites to find potential compounds. | MINISTRY OF EDUCATION VIETNAM ACADEMY AND TRAINING OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ----------------------------- LE CANH VIET CUONG STUDY ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF SEVERAL ANTIDESMA SPECIES GROWING IN VIETNAM Major Organic chemistry Code 62.44.01.14 SUMMARY OF CHEMISTRY DOCTORAL THESIS Hanoi - 2017 This thesis was completed at Graduate University Science and Technology - Vietnam Academy of Science and Technology Adviser 1 Assoc. Prof. Dr. Phan Van Kiem Adviser 2 Assoc. Prof. Dr. Le Mai Huong 1st Reviewer 2nd Reviewer 3rd Reviewer The thesis will be defended at Graduate University of Science and Technology - Vietnam Academy of Science and Technology at hour date month 2017 Thesis can be found in The library of the Graduate University of Science and Technology Vietnam Academy of Science and Technology. 1 INTRODUCTION 1. The urgency of the thesis The World Health Organization WHO had estimated that as much as 80 percent population relies on traditional medicines in deverloping countries especially medicinal plants. In the process of drugs discovery and development traditional knowledge and experiential databases were considered to be one of the important factors which could be increased success rate of lead compounds by reducing the consumed time and money spent as well as toxic occurrence. Therefore investigations on medicinal plants still remain attractive and stimulate attention of scientists worldwide. According to Dictionary of Vietnamese medicinal plants Vo Van Chi 2003 in Vietnam there were 11 species of the Antidesma genus which were used to treat stomachache syphilis measles chickenpox menstrual diseases . Phytochemical investigation of Antidesma genus led to the isolation of numerous alkaloids terpenoids steroids megastigmanes flavonoids lignans and other phenolic compounds. In addition a lot of extractions and isolated compounds exhibited potent anticancer anti-oxidant antidiabetic .