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Utilizing protein structure to identify non-random somatic mutations

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Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key “driver” mutations responsible for tumorigenesis. |

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Báo cáo khoa học: "Effect of Utilizing Terminology on Extraction of Protein-Protein Interaction Information from Biomedical Literature"

Utilizing protein structure to identify non-random somatic mutations

Utilizing knowledge base of amino acids structural neighborhoods to predict protein-protein interaction sites

A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations