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Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development

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The embryonic day E10–13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiated by the formation of the epicardium on the outer heart surface, which releases insulinlike growth factor 2 (IGF2) as the primary cardiomyocyte mitogen. |

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