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Effects of Mecp2 loss of function in embryonic cortical neurons: A bioinformatics strategy to sort out non-neuronal cells variability from transcriptome profiling
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Mecp2 null mice model Rett syndrome (RTT) a human neurological disorder affecting females after apparent normal pre- and peri-natal developmental periods. Neuroanatomical studies in cerebral cortex of RTT mouse models revealed delayed maturation of neuronal morphology and autonomous as well as non-cell autonomous reduction in dendritic complexity of postnatal cortical neurons. |