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The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding

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The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in over 70% of ER negative tumors. This prompted us to investigate the phenotypic and gene expression effects of loss of WWOX expression in breast cells. |

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