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Quantitative measurements of HER2 and phospho-HER2 expression: Correlation with pathologic response to neoadjuvant chemotherapy and trastuzumab

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Preoperative therapy with chemotherapy and the HER2-targeted monoclonal antibody trastuzumab is valuable for patients with large or locally advanced HER2-positive (HER2+) breast cancers but traditional methods of measuring HER2 expression do not accurately stratify patients for likelihood of response. |