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Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis

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Identification of patients with oral dysplasia at high risk of cancer development and oral squamous cell carcinoma (OSCC) at increased risk of disease recurrence will enable rigorous personalized treatment. Regulated intramembranous proteolysis of Epithelial cell adhesion molecule (EpCAM) resulting in release of its intracellular domain Ep-ICD into cytoplasm and nucleus triggers oncogenic signaling. |

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Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis