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Ruxolitinib in GvHD (RIG) study: A multicenter, randomized phase 2 trial to determine the response rate of Ruxolitinib and best available treatment (BAT) versus BAT in steroid-refractory acute graft-versushost disease (aGvHD) (NCT02396628)

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Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. | Ruxolitinib in GvHD RIG study A multicenter randomized phase 2 trial to determine the response rate of Ruxolitinib and best available treatment BAT versus BAT in steroid-refractory acute graft-versushost disease aGvHD NCT02396628