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Non-antibiotic compounds: The activity of the NSAID diclofenac on bacteria - A review

Bacterial multidrug resistanceis a phenomenon that has been growing with increasing speed worldwide. New mechanisms of resistance have been described in different bacterial pathogens, representing a threat to effective treatments of common infectious diseases with currently available drugs. The use of drugs known as "non-antibiotics are among the alternative approaches to the use of conventional antibiotics. This approach has been studied in order to counteract the global threat of multidrug resistance. This group of drugs includes various non-steroidal anti-inflammatory drugs (NSAIDs). The NSAID diclofenac has demonstrated broad-spectrum antimicrobial activity in vitro and in vivo. In addition, this drug has an synergistic antibacterial effect when combined with certain other drugs. It may also show anti-biofilm activity, and may inhibit or decrease the activity of certain virulence factors in some bacterial pathogens. | Non-antibiotic compounds The activity of the NSAID diclofenac on bacteria - A review