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Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: Neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)

Whole brain radiation therapy (WBRT) is the standard therapy for multiple brain metastases. However, WBRT has a poor local tumor control and is associated with a decline in neurocognitive function (NCF). | Whole-brain irradiation with hippocampal sparing and dose escalation on metastases Neurocognitive testing and biological imaging HIPPORAD a phase II prospective randomized multicenter trial NOA-14 ARO 2015 3 DKTK-ROG