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A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice
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Cytotoxic chemotherapeutics form the cornerstone of systemic treatment of many cancers. Patients are dosed at maximum tolerated dose (MTD), which is carefully determined in phase I studies. In contrast, in murine studies, dosages are often based on customary practice or small pilot studies, which often are not well documented. | A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice