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Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells

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Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms of chemoresistance in LRCC remain to-date incompletely understood. | Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells

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