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R269C variant of ESR1: High prevalence and differential function in a subset of pancreatic cancers

Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge region, connecting the ligand binding and DNA domains. | R269C variant of ESR1 High prevalence and differential function in a subset of pancreatic cancers