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DPD status and fluoropyrimidines-based treatment: High activity matters too

Dihydropyrimidine dehydrogenase (DPD) status is an indicator of a marked risk for toxicity following fluoropyrimidine (FP)-based chemotherapy. This notion is well-established for low DPD status but little is known about the clinical impact of high DPD activity. | DPD status and fluoropyrimidines-based treatment High activity matters too