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Crosslinked flagella as a stabilized vaccine adjuvant scaffold

Engineered vaccine proteins incorporating both antigen and adjuvant components are constructed with the aim of combining functions to induce effective protective immunity. Bacterial flagellin is a strong candidate for an engineered vaccine scaffold as it is known to provide adjuvant activity through its TLR5 and inflammasome activation. | Crosslinked flagella as a stabilized vaccine adjuvant scaffold