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VARSCOT: Variant-aware detection and scoring enables sensitive and personalized off-target detection for CRISPR-Cas9

Natural variations in a genome can drastically alter the CRISPR-Cas9 off-target landscape by creating or removing sites. Despite the resulting potential side-effects from such unaccounted for sites, current off-target detection pipelines are not equipped to include variant information. | VARSCOT: Variant-aware detection and scoring enables sensitive and personalized off-target detection for CRISPR-Cas9