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The protocol for the Cannabidiol in children with refractory epileptic encephalopathy (CARE-E) study: A phase 1 dosage escalation study

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Initial studies suggest pharmaceutical grade cannabidiol (CBD) can reduce the frequency of convulsive seizures and lead to improvements in quality of life in children affected by epileptic encephalopathies. With limited access to pharmaceutical CBD, Cannabis extracts in oil are becoming increasingly available. | The protocol for the Cannabidiol in children with refractory epileptic encephalopathy (CARE-E) study: A phase 1 dosage escalation study