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Structurally simple synthetic 1, 4- disubstituted piperidines with high selectivity for resistant Plasmodium falciparum

Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. Fourteen synthetic 1, 4-disubstituted piperidines with simple molecular structures were evaluated in this study. | Structurally simple synthetic 1, 4- disubstituted piperidines with high selectivity for resistant Plasmodium falciparum