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Chemical constituents of Euphorbia tirucalli L.

Euphorbia tirucalli has not been chemically studied much in Vietnam. This research described the isolation and elucidation of compounds isolated from the plant collected in Binh Thuan. Multiple chromatographic methods were applied, including normal phase silica gel column chromatography and thin-layer chromatography. Seven compounds were isolated and their chemical structures were elucidated by spectroscopic analysis as well as comparing their data with the ones in the literature | 76 SCIENCE TECHNOLOGY DEVELOPMENT JOURNAL NATURAL SCIENCES VOL 2 ISSUE 5 2018 Chemical constituents of Euphorbia lirucalli L. Le Thi Kim Dung Bui Xuan Hao Nguyen Thi Anh Tuyet Pham Nguyen Kim Tuyen Duong Thuc Huy Abstract Euphorbia tirucalli has not been chemically studied much in Vietnam. This research described the isolation and elucidation of compounds isolated from the plant collected in Binh Thuan. Multiple chromatographic methods were applied including normal phase silica gel column chromatography and thin-layer chromatography. Seven compounds were isolated and their chemical structures were elucidated by spectroscopic analysis as well as comparing their data with the ones in the literature. They are arjunolic acid 1 eriodictyol 2 quercitrin 3 afzelin 4 scopoletin 5 3 3 4- trimethylellagic acid 6 and gallic acid 7 . Among them compound 1 a major component was isolated for the first time in Euphorbia genus while three compounds 2 4 and 5 were isolated from this species for the first time. Keywords arjunolic acid phenolic compounds flavonoid Euphorbia tirucalli 1. INTRODUCTION f. uphorbia tirucalli L. belongs to the i Enphorbiaceae family and is a very popular herb in traditional herbal medicine 1 . There are approximately 1600 species in the Euphorbia genus. Some species of this genus have long been used as herbal drugs in China India Brazil and Southeast Asia. Euphorbia tirucalli L. is traditionally used in Vietnam. The extract and pure compounds from Euphorbia tirucalli were evaluated some biological activity including antioxidant and antimicrobial 3 antifungal antiviral 4 anti-inflammatory 5 cytotoxicity 6 and enzyme inhibitory activities 7 . Previous phytochemical investigation on the plant Euphorbia tirucalli reported the presence of phytosterols tritepenes diterpenes polyphenols Received 29-05-2017 Accepted 12-10-2018 Published 2011-2018 Le Thi Kim Dung1 Bui Xuan Hao1 Nguyen Thi Anh Tuyet1 Pham Nguyen Kim Tuyen2 Duong Thuc Huy1 -1University of Pedagogy -