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Peptides as therapeutic agents for dengue virus

Dengue is an important global threat caused by dengue virus (DENV) that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine, its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. | Int. J. Med. Sci. 2017 Vol. 14 1342 international publisher internationaL journal Oj jVLeaiCai Sciences 2017 14 13 1342-1359. doi 10.7150 ijms.21875 Review Peptides as Therapeutic Agents for Dengue Virus Miaw-Fang Chew1 Keat-Seong Poh2 and Chit-Laa Poh1E 1. Research Centre for Biomedical Sciences Sunway University Bandar Sunway Selangor 47500 Malaysia 2. Department of Surgery Faculty of Medicine University of Malaya Jalan Universiti Kuala Lumpur 50603 Malaysia. El Corresponding author Chit-Laa Poh Address Research Centre for Biomedical Sciences Sunway University 5 Jalan Universiti Malaysia. Phone No. 6 03 7491 8622 ext. 7338 Fax No 6 03 5635 8630 Email address pohcl@sunway.edu.my Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution CC BY-NC license https creativecommons.org licenses by-nc 4.0 . See http ivyspring.com terms for full terms and conditions. Received 2017.07.12 Accepted 2017.09.01 Published 2017.10.15 Abstract Dengue is an important global threat caused by dengue virus DENV that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. There is therefore an urgent need for the development of antiviral drugs for the treatment of dengue. Peptide was once a neglected choice of medical treatment but it has lately regained interest from the pharmaceutical industry following pioneering advancements in technology. In this review the design of peptide drugs antiviral activities and mechanisms of peptides and peptidomimetics modified peptides action against dengue virus are discussed. The development of peptides as inhibitors for viral entry replication and translation is also described with a focus on the three main targets namely the host cell receptors viral structural proteins and viral non-structural proteins. The antiviral peptides designed