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Pluronic – Grafted Copolymers as Nanoplatforms for

Several kinds of anticancer drugs have significantly contributed in cancer therapy but these drugs exhibited several side-effect. There has recently been an emerging approach in drug development by which efficient exploitation of using nanocarriers. The drug delivery nanocarriers are considering as a sustainable and innovative development. | Advances in Research 8 1 1-11 2016 Article no.AIR.28869 ISSN 2348-0394 NLM ID 101666096 SCIENCEDOMAIN international www. sciencedomain. org Pluronic - Grafted Copolymers as Nanoplatforms for Effectively Delivering Hydrophobic Anticancer Drugs Ngoc The Nguyen1 T. T. Thuy Nguyen2 Phuong Do2 T. T. Chau Nguyen3 Van Toan Nguyen4 Dai Hai Nguyen2 Cuu Khoa Nguyen2 and Ngoc Quyen Tran1 2 1Department of Pharmacy and Medicine Tra Vinh University Tra Vinh City Vietnam. 2Department of Materials and Pharmaceutical Chemistry Institute of Applied Materials Science Vietnam Academy of Science and Technology VAST HCMC 70000 Vietnam. 3Department of Chemical Engineering Industrial University of Ho Chi Minh City HCMC HCMC70000 Vietnam. 4Department of Chemistry and Food Technology Ba Ria-Vung Tau University Vung Tau City Vietnam. Authors contributions This work was carried out in collaboration between all authors. All authors read and approved the final manuscript. Article Information DOI 10.9734 AIR 2016 28869 Editor s 1 Ayman M. Noreddin Chair Department of Pharmacy Practice School of Pharmacy Hampton University Graduate faculty East Virginia Medical School USA. Reviewers 1 Xiaohong Hu Jinling Institute of Technology Nanjing China. 2 Miloslav Milichovsky University of Pardubice Czech Republic. Complete Peer review History http www.sciencedomain.org review-history 16220 Original Research Article Received 10th August 2016 Accepted 3rd September 2016 Published 16th September 2016 ABSTRACT Several kinds of anticancer drugs have significantly contributed in cancer therapy but these drugs exhibited several side-effect. There has recently been an emerging approach in drug development by which efficient exploitation of using nanocarriers. The drug delivery nanocarriers are considering as a sustainable and innovative development. In these studies two kinds of pluronic-conjugated polymers were prepared in a green synthetic process via conjugate of thermosensitive copolymer pluronic F127 F127 .