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Melatonin and vitamin D orchestrate adipose derived stem cell fate by modulating epigenetic regulatory genes

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Melatonin, that regulates many physiological processes including circadian rhythms, is a molecule able to promote osteoblasts maturation in vitro and to prevent bone loss in vivo, while regulating also adipocytes metabolism. In this regard, we have previously shown that melatonin in combination with vitamin D, is able to counteract the appearance of an adipogenic phenotype in adipose derived stem cells (ADSCs), cultured in an adipogenic favoring condition. | Melatonin and vitamin D orchestrate adipose derived stem cell fate by modulating epigenetic regulatory genes

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