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Adult osteoporosis with a history of childhood-onset fracture due to an lrp5 receptor variant mutation

This case highlights the value of genetic screening for idiopathic osteoporosis with recurrent fractures. This case highlights the variability in clinical expression of LRP5 polymorphisms and suggests that standard treatment in cases of recurrent fracture may be ineffective. (AACE Clinical Case Rep. 2019;5:e362-e364) | Adult osteoporosis with a history of childhood-onset fracture due to an lrp5 receptor variant mutation