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Study on application of multiplex ligation dependent probe amplification (MLPA) assay in molecular diagnosis of retinoblastoma

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Retinoblastoma (Rb) is a malignant retinal tumor on young children which is often founded before the age of 5. This cancer disease appears when both of RB1 alleles on 13q14.2 chromosome are mutated. The aim of this research is to evaluate the ability of Multiplex Ligation-dependent Probe Amplification (MLPA) in screening of RB1 gene insertion/deletions in Vietnamese patients with Rb. | Study on application of multiplex ligation dependent probe amplification (MLPA) assay in molecular diagnosis of retinoblastoma

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