Đang chuẩn bị liên kết để tải về tài liệu:
Treatment results of locally advanced cervical cancer by external beam radiotherapy and low dose rate brachytherapy at Hue Central Hospital

To evaluate the outcome of external beam radiotherapy plus low-dose-rate brachytherapy for locally advanced cervical cancer treatment in reccurrence, metastasis, survivals and complications. | Journal of military pharmaco-medicine no1-2019 TREATMENT RESULTS OF LOCALLY ADVANCED CERVICAL CANCER BY EXTERNAL BEAM RADIOTHERAPY AND LOW DOSE RATE BRACHYTHERAPY AT HUE CENTRAL HOSPITAL Phan Canh Duy1; Nguyen Thanh Ai1; Pham Nhu Hiep1 SUMMARY Objectives: To evaluate the outcome of external beam radiotherapy plus low-dose-rate brachytherapy for locally advanced cervical cancer treatment in reccurrence, metastasis, survivals and complications. Subjects and methods: A prospective study on 96 patients with locally advanced cervical cancer treated by radical radiotherapy (external beam radiotherapy + 137 low-dose-rate brachytherapy using Césium) at Oncology Center of Hue Central Hospital from 2005 to 2012. Results: Common recurrence rate was 13.5%; local recurrence rate was 38.5%, and extensive invasion was 61.5%; meantime of recurrence was 13.0 ± 11.9 months (1.5 - 36.0 months). Common metastasis rate was 16.7%; mean time of metastatis was 10.7 ± 7.5 months, lung metastasis was 25.0%, bone 25.0%, supraclavicular lymph node 18.8%, paraaortic lymph node 12.5%, liver 6.3%. Mean overall survival was 6.3 ± 0.3 years. Mean follow-up period was 4.1 years (0.3 - 7.6 years). 5 year overall survival was 75.9%; 5 year overall survival of stage IIA was 85.7%, stage IIB was 80.2%, stage IIIA: 77.8% and stage IIIB: 65.5% (p = 0.357). Post-radiotherapy complications: hemorrhage bladder inflammation was 1.0%, with the time of occurrence was 22 months. Hemorrhage protitis was 5.2%, with mean time of occurrence was 23.8 ± 3.9 months (18.0 - 28.0 months). Sacrococcyx ulcer was 1.0%, time of occurrence was 10.0 months. Conclusions: External beam radiotherapy plus external beam radiotherapy brachytherapy in treatment of locally advanced cervical cancer improved outcomes of reccurrence, metastasis, complications, overall survival and disease free survival. Radioactive 137 source of external beam radiotherapy brachytherapy is Césium that has a long half life, therefore it is suitable for .