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Research on clinical characteristics, immunohistochemistry and mutation of BRAF gene in patients with thyroid carcinoma

To study clinical characteristics, immunohistochemistry and mutation of BRAF gene in patients with thyroid carcinoma. The case, cross-sectional and non-control descriptive study was conducted on 102 patients diagnosed with thyroid carcinoma by histopathology at Thoracic Surgery Department of 103 Military Hospital. | Journal of military pharmaco-medicine no9-2018 RESEARCH ON CLINICAL CHARACTERISTICS, IMMUNOHISTOCHEMISTRY AND MUTATION OF BRAF GENE IN PATIENTS WITH THYROID CARCINOMA Bui Dang Minh Tri1; Mai Van Vien2 Nghiem Duc Thuan3; Tran Ngoc Dung3 SUMMARY Objectives: To study clinical characteristics, immunohistochemistry and mutation of BRAF gene in patients with thyroid carcinoma. Subjects and methods: The case, cross-sectional and non-control descriptive study was conducted on 102 patients diagnosed with thyroid carcinoma by histopathology at Thoracic Surgery Department of 103 Military Hospital. Results: Majority of patients were in the age of 30 - 49 years old (47%); the female/male ratio was 4.67/1. Symptoms included: Tumor on the right side accounted for the highest rate (34.3%). Majority were with hard density, firmness tumors (87.3%), majority of patients got 1 thyroid tumor (52.0%). 84.3% of thyroid carcinoma patients were differentiated at T2 level, 2 cases (2%) were at T3 level, 13.7% of patients were at T1 level, 11.8% had nodal metastases before surgery. Average size of metastases nodes was 1.80 ± 0.94 cm. No case had distant metastases. 52% of thyroid carcinoma patients in phase I; 48% in phase II - III. 99% of patients were positive with HBME-1 and 100% of patients were positive with CK19, 62.7% positive with COX-2; 52.9% positive with p53; 32.4% positive with Ki67 and 89.2% positive with RET. 60.8% of patients had BRAF gene mutation at T1799A (V600E). Conclusions: Patients with thyroid carcinoma had a variety of clinical manifestations when they came for consultation. Immunohistochemistry and BRAF gene mutation were valuable markers in the diagnosis of thyroid carcinoma. * Keywords: Thyroid cancer; Thyroid carcinoma; BRAF gene mutation; Clinical characteristics. INTRODUCTION Thyroid carcinoma is the most common endocrine cancer. In the last 30 years, many countries have recorded a significant increasing in the incidence of thyroid carcinoma, a worldwide study