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Sesquiterpene phenols from marine sponge Smenospongia cerebriformis

Using various chromatography methods, four sesquiterpene phenols, dictyoceratin C (1), polyfibrospongol A (2), polyfibrospongol B (3), and 19-hydroxy-polyfibrospongol B (4) were isolated from the methanol extract of the Vietnamese marine sponge Smenospongia cerebriformis. Their structures were determined by 1D-, 2D-NMR spectra, HR-ESI-MS and in comparison with those reported in the literature. | Vietnam Journal of Chemistry, International Edition, 55(2): 148-152, 2017 DOI: 10.15625/2525-2321.2017-00434 Sesquiterpene phenols from marine sponge Smenospongia cerebriformis Le Thi Huyen1, Dan Thi Thuy Hang2, Nguyen Xuan Nhiem2, Bui Huu Tai2, Hoang Le Tuan Anh2, Pham Hai Yen2, Nguyen Van Dau1, Chau Van Minh2, Phan Van Kiem2* 1 2 Hanoi University of Science, Vietnam National University (VNU) Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) Received 19 November 2016; Accepted for publication 11 April 2017 Abstract Using various chromatography methods, four sesquiterpene phenols, dictyoceratin C (1), polyfibrospongol A (2), polyfibrospongol B (3), and 19-hydroxy-polyfibrospongol B (4) were isolated from the methanol extract of the Vietnamese marine sponge Smenospongia cerebriformis. Their structures were determined by 1D-, 2D-NMR spectra, HR-ESI-MS and in comparison with those reported in the literature. Keywords. Smenospongia cerebriformis, sponge, sesquiterpene phenol. 1. INTRODUCTION Sesquiterpenes were found as a main components of the genus Smenospongia. These compounds represent a prominent class of biologically active metabolites. Several chemical investigations have been focused on the marine sponge Smenospongia cerebriformis. The components of this genus were identified as sesquiterpenes [1, 2], indole alkaloids [2-4] and phenyl alkene [5]. They exhibited some biological activities such as anti-human cancer [1, 5] and antidepressant [2]. We reported herein the isolation and structure elucidation of four sesquiterpene phenols from the Vietnamese marine sponge Smenospongia cerebriformis. 2. MATERIALS AND METHODS 2.1. Sponge materials The sponge Smenospongia cerebriformis (Duchassaing & Michelotti, 1864) was collected in Vinhmoc, Quangtri in August 2015 and identified by Assoc. Prof. Do Cong Thung, Institute of Marine Environment and Resources, VAST. A voucher specimen (HM08.2015-2) was deposited at the Institute of .