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Tetraoxygenated xanthones from the latex of garcinia cowa growing in Viet Nam

Seven tetraoxygenated xanthones, namely fuscaxanthone A, 7-O-methylgarcinone E, cowagarcinone A, cowaxanthone, rubraxanthone, cowanin and cowanol, were isolated from the dichloromethane extract of the latex of Garcinia cowa Roxb. ex Choisy. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and compared with reported data. This is the first time the chemical constituents of Garcinia cowa Roxb. ex Choisy have been investigated in Vietnam. | Vietnam Journal of Science and Technology 56 (5) (2018) 560-566 DOI: 10.15625/2525-2518/56/5/11826 TETRAOXYGENATED XANTHONES FROM THE LATEX OF GARCINIA COWA GROWING IN VIET NAM Nguyen Thi Kim An1, 2, *, Dinh Thi Ha3, Pham Quoc Long3, Tran Thi Thu Thuy3 1 School of, Hanoi University of Industry, Minh Khai ward, Tu Liem district, Ha Noi 2 School of, Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 3 Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi * Email: kimansp@gmail.com Received: 16 March 2018; Accepted for publication: 11 June 2018 Abstract. Seven tetraoxygenated xanthones, namely fuscaxanthone A, 7-O-methylgarcinone E, cowagarcinone A, cowaxanthone, rubraxanthone, cowanin and cowanol, were isolated from the dichloromethane extract of the latex of Garcinia cowa Roxb. ex Choisy. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and compared with reported data. This is the first time the chemical constituents of Garcinia cowa Roxb. ex Choisy have been investigated in Vietnam. Keywords: tetraoxygenated xanthone, dichloromethane extract, latex, Garcinia cowa. Classification numbers: 1.1.1; 1.1.6; 1.4.7. 1. INTRODUCTION Garcinia cowa Roxb. ex Choisy (G. cowa), Clusiaceae family is widely distributed in Vietnam. The root and barks of G. cowa have been used in traditional medicine for treatment of fever or as antiseptic agent [1]. The fruits and young leaves of the tree are edible and are consumed popularly in Southeast Asian countries. Phytochemical studies and pharmacological activities of G. cowa from Thailand were reported recently [2 - 6]. According to previous reports, main chemical constituents of G. cowa are xanthones which were demonstrated interesting bioactivities such as antimalarial [2], antimicrobial [3, 5, 7], anti-inflammatory [4, 8], antioxidant [3, 4, 9], antibacterial [5, 10, 11], antitumor-promoting activity [12] and cytotoxic activities