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Study of gram-negative bacteris resistance to antibiotics causing nosocomial pneumonia in patients with stroke at 103 Military Hospital

The article presents assessment of antibiotic resistance of gram-negative bacteria causing nosocomial pneumonia in stroke patients at 103 Military hospital. | Journal of military pharmaco-medicine no2-2018 STUDY OF GRAM-NEGATIVE BACTERIA RESISTANCE TO ANTIBIOTICS CAUSING NOSOCOMIAL PNEUMONIA IN PATIENTS WITH STROKE AT MILITARY HOSPITAL 103 Dang Phuc Duc*; Nguyen Minh Hien* Mai Xuan Khan*; Nguyen Thai Son* SUMMARY Objectives: To evaluate the antibiotic resistance of Gram-negative bacteria causing pneumonia in stroke patients. Methods: Descriptive study. Results: P. aeruginosa resistance > 80% was observed in most antibiotics (14/20 patients), 100% was resistant to imipenem, norfloxacin; sensitivity to polymycin (100%). K. pneumoniae strains 100% with 8/20 antibiotics, including ciprofloxacin, cefpirome, cefuroxime. K. pneumoniae strains were sensitivity 100% to doxycylins and carbapenem antibiotics. A. baumannii strains resist 100% to 5 antibiotics, including piperacillin + tazobactam; 50% of A. baumannii strains resist to the carbapenem group. * Keywords: Nosocomial pneumonia; Antibiotic resistance; Stroke. INTRODUCTION Stroke patients have many potential risk factors for nosocomial pneumonia such as: poor mobility due to paralysis, swallowing disorders, immuno-depression, mechanical ventilation. Most causes of pneumonia are Gram-negative bacteria. Antibiotic resistance of bacteria, especially Gram-negative bacteria is increasing and causing difficulties in treatment. We conducted this study aiming at: Assessment of antibiotic resistance of Gram-negative bacteria causing nosocomial pneumonia in stroke patients at 103 Military Hospital. SUBJECTS AND METHODS 1. Subjects. 215 patients were diagnosed with stroke at Department of Stroke, 103 Military Hospital, divided into two groups: pneumonia and non-pneumonia. * Inclusion criteria: - American Thoracic Society's 2005 nosocomial pneumonia diagnostic criteria: - Pneumonia appears after hospitalization > 48 hours. - The presence of a new or progressive radiographic infiltrate plus at least two of three clinical features. - Fever greater than 38oC. - Leukocytosis or .