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Study on neuronal activities of anterior cingulate during social behavior in monkey

The results indicated that activity of some neurons was significantly correlated with one or more of social behaviors. Activity of leaving- and approaching-related neurons changed in response to leaving and approaching behaviors of recording and/or partner monkeys, respectively. | Journal of military pharmaco-medicine 7-2013 STUDY ON NEURONAL ACTIVITIES OF ANTERIOR CINGULATE DURING SOCIAL BEHAVIOR IN MONKEY Can Van Mao*; Etsuro Hori**; Hisao Nishijo** summary Previous studies indicated that the anterior cingulate cortex (ACC) is one of the critical brain areas for social behaviors, and that the effects of PCP might be mediated through the ACC. However, few studies investigated neural correlates with social behaviors in the ACC. To investigate this issue, we recorded ACC neuronal activity from one of the 2 monkeys while these 2 monkeys socially interacted. The results indicated that activity of some neurons was significantly correlated with one or more of social behaviors. Activity of leaving- and approaching-related neurons changed in response to leaving and approaching behaviors of recording and/or partner monkeys, respectively. Activity of the communication-related neurons changed while the 2 monkeys engaged themselves in a series of social behaviors such as grooming together, lip smacking, facing, etc. These results provide neurophysiological bases for ACC involvement in psychiatric disorders with social disturbance such as schizophrenia, austism. * Key word: Neural mechanisms; Social interaction. Introduction Disturbances in social skills (e.g. avoiding social contact, neglecting a surrounding environment, social isolation) are pervasive aspects of many diseases such as: schizophrenia, autism, bipolar disorder. However, neural mechanisms of these social deficits in these diseases are still unclear. The anterior cngulate cortex (ACC) is one of the pivotal components in the brain network [6], and implicated in cognition, decision making, emotion and social behaviors [9]. The previous behavioral studies reported that lesions of the ACC induced deficits in social behaviors in monkeys. Post-mortem and clinicopathological studies using individuals with schizophrenia indicated deficits in the ACC; decreased gray matter volume, and reduced