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Antipyretic activity of peperomia pellucida leaves in rabbit

Antipyretic effects of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of Peperomia pellucida (Linn.) HBK (Fam. Piperaceae) were investigated. Intraperitoneal administration of boiled milk at a dose of 0.5 ml/kg body weight in albino rabbit leads to pyrexia. | Turk J Biol 32 (2008) 37-41 © TÜB‹TAK Antipyretic Activity of Peperomia pellucida Leaves in Rabbit 1 2 2 Alam KHAN , Moizur RAHMAN , Shariful ISLAM 1 Department of Pharmacy, University of Rajshahi, Rajshahi 6205, BANGLADESH 2 Department of Animal Husbandry and Veterinary Science, University of Rajshahi, Rajshahi 6205, BANGLADESH Received: 08.05.2007 Abstract: Antipyretic effects of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of Peperomia pellucida (Linn.) HBK (Fam. Piperaceae) were investigated. Intraperitoneal administration of boiled milk at a dose of 0.5 ml/kg body weight in albino rabbit leads to pyrexia. Intraperitoneal (i.p.) administration of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of P. pellucida at a dose of 80 mg/kg body weight significantly reduced the elevated body temperature of rabbit. This antipyretic effect has been compared with antipyretic effect of standard aspirin and the solvent used. Key Words: Peperomia pellucida, leaves, antipyretic, rabbits, boiled milk, aspirin Peperomia pellucida Yapraklar›n›n Tavflanlar Üzerine Atefl Düflürücü Etkisi Özet: Peperomia pellucida (Linn.) HBK (Fam. Piperaceae) yapraklar›n›n etanol ekstraktlar›n›n petrol eter ve etil asetatta çözünen fraksiyonlar›n›n antipiretik (atefl düflürücü) etkileri araflt›r›lm›flt›r. Kaynat›lm›fl sütün periton kesesi içine 0,5 ml/kg vücüt a¤›rl›¤› dozunda uygulanmas› albino tavflanlarda yüksek atefle neden olmaktad›r. P. pellucida yapraklar›n›n etanol ekstraktlar›n›n petrol eter ve etil asetatta çözünen fraksiyonlar›n›n periton kesesi içine 80 mg/kg vücüt a¤›rl›¤› dozunda uygulanmas› tavflan›n artm›fl olan vücüt s›cakl›¤›n› belirgin olarak düflürmüfltür. Bu atefl düflürücü etki standart aspirin ve kullan›lan çözücünün atefl düflürücü etkisi ile karfl›laflt›r›lm›flt›r. Anahtar Sözcükler: Peperomia pellucida, yapraklar, atefl düflürücü, tavflan, kaynam›fl süt, aspirin Introduction Peperomia pellucida (Linn.) HBK .