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Investigation of coronary artery disease in patients with essential hypertension by dual-source 256-slide msct

Objectives: To investigate coronary artery lesions in patients with essential hypertension by Dual-source 256-slide MSCT compared to percutaneous coronary angiography. Subjects and methods: 186 patients were enrolled. All of them underwent 256-slide MSCT in Vietnam Heart Institute from 11 - 2014 to 10 - 2016. | Journal of military pharmaco-medicine no5-2017 INVESTIGATION OF CORONARY ARTERY DISEASE IN PATIENTS WITH ESSENTIAL HYPERTENSION BY DUAL-SOURCE 256-SLIDE MSCT To Thi Mai Hoa*; Pham Thi Hong Thi**; Pham Minh Thong** SUMMARY Objectives: To investigate coronary artery lesions in patients with essential hypertension by Dual-source 256-slide MSCT compared to percutaneous coronary angiography. Subjects and methods: 186 patients were enrolled. All of them underwent 256-slide MSCT in Vietnam Heart Institute from 11 - 2014 to 10 - 2016. Results: The percentage of significant coronary stenosis was 47.8%. The number of 1, 2 and 3 branches with stenosis accounted for 19.9%, 16.1% and 11.8%, respectively. Almost patients were suffered from diffuse coronary injury: LAD, RCA, LCx, LM stenosis at 41.4%, 24.7%, 18.8% and 4.3%, respectively. The proportion of patients with severe stenosis was 49.6%. The percentages of LAD and RCA were higher than others. Patients with hypertension also suffered coronary calcification. Conclusion: Dual-source 256slide MSCT is not only a non-invasive approach of coronary disease, but also should be used to assess patients with essential hypertension and coronary artery disease (CAD). * Key words: Hypertension; Coronary artery disease; 256-slide computed tomography. INTRODUCTION Hypertension is one of the most common diseases and has a high mortality rate. It is also a highly prevalent risk factor for cardiovascular diseases throughout the industrialized world. According to World Health Organization (WHO), worldwide hypertension is estimated to cause 7.1 million premature deaths and 4.5% of the disease burden [5]. Despite of the universal acknowledgment, hypertension should be diagnosed and aggressively treated, blood pressure control rates around the world are abysmally low and shameful [5]. Coronary artery disease is one of the leading causes threating human health in developed countries and it increasingly becoming a significant public health .