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Study on some histopathological features and expression of some immunohistochemical markers in prostatic carcinoma

Objectives: To determine some histopathological features and evaluate the expression of some IHC markers in prostate carcinoma (Pca). Subjects and methods: Histopathological study was performed on 84 specimens by using hematoxylin and eosin (H.E) stained tissue sections. IHC study was performed on 33 specimens by using IHC stained tissue sections with PSA, CK34βE12, p63, CK7, CK5/6, actin monoclonal antibodies. | Journal of military pharmaco-medicine n08-2017 STUDY ON SOME HISTOPATHOLOGICAL FEATURES AND EXPRESSION OF SOME IMMUNOHISTOCHEMICAL MARKERS IN PROSTATIC CARCINOMA Vi Thuat Thang*; Tran Ngoc Dung*; Nguyen Dinh Tao** Nguyen Ngoc Hung*; Tran Ngoc Anh** SUMMARY Objectives: To determine some histopathological features and evaluate the expression of some IHC markers in prostate carcinoma (Pca). Subjects and methods: Histopathological study was performed on 84 specimens by using hematoxylin and eosin (H.E) stained tissue sections. IHC study was performed on 33 specimens by using IHC stained tissue sections with PSA, CK34βE12, p63, CK7, CK5/6, actin monoclonal antibodies. Results: Prostatic adenocarcinoma accounted for 96.4% (acinar type was the most common) and urothelial carcinoma of the prostate accounted for 3.6%. Gleason scores 5 - 7 were the most common. Of the 84 patients, 60 (73.2%) had high grade prostatic intraepithelial neoplasia (HGPIN) associated adenocarcinoma. There were 39% of adenocarcinoma with perineural invasion and 53.7% of adenocarcinoma with mucinous secretions. IHC showed 31 cases (94%) of Pca which were positive for PSA and 2 cases (6%) of urothelial carcinoma of the prostate were negative for PSA. The lower Gleason grade was stronger positive for PSA was and vice versa. All the tumor cells were negative for 34βE12, p63, CK7, CK5/6 and actin. Conclusion: Our data indicate that most of Pca are prostatic adenocarcinoma and Gleason scores 5 - 7 are the most common scores. HGPIN is strongly associated with adenocarcinoma. Other features are commonly seen in prostatic adenocarcinoma which are blue-tinged mucinous secretions and perineural invasion. IHC shows all of prostatic adenocarcinomas are positive for PSA, urothelial carcinoma of the prostate is negative for PSA. The staining intensity of the tumor cells for PSA is stronger in the lower grade adenocarcinomas and vice versa. * Keywords: Adenocarcinoma of the prostate; .