Đang chuẩn bị liên kết để tải về tài liệu:
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

 Less than 3 decades ago, Robin Warren and Barry Marshall definitively identified Helicobacter pylori by culturing an organism from gastric biopsy specimens that had been visualized for almost a century by pathologists (196). In 1994, H. pylori was recognized as a type I carcinogen, and now it is considered the most common etiologic agent of infection-related cancers, which represent 5.5% of the global cancer burden (239). In 2005, Marshall and Warren were awarded the Nobel Prize of Medicine for their seminal discovery of this bacterium and its role in peptic ulcer disease | Vol. 23 No. 4 Clinical Microbiology Reviews Oct. 2010 p. 713-739 0893-8512 10 12.00 doi 10.1128 CMR.00011-10 Copyright 2010 American Society for Microbiology. All Rights Reserved. Helicobacter pylori and Gastric Cancer Factors That Modulate Disease Risk Lydia E. Wroblewski 1 Richard M. Peek Jr. 1 2 3 and Keith T. Wilson1 2 3 Division of Gastroenterology Department of Medicine 1 and Department of Cancer Biology 2 Vanderbilt University Medical Center Nashville Tennessee 37232 and Department of Veterans Affairs Medical Center Nashville Tennessee 372123 INTRODUCTION.714 Helicobacter pylori.714 Gastric Cancer.714 H. PYLORI VIRULENCE FACTORS.715 cag PAI.715 CagA.715 CagA phosphorylation-dependent host cell signaling.716 CagA phosphorylation-independent host cell signaling.716 Peptidoglycan.716 VacA Toxin.717 Consequences of VacA within the host cell.717 Adhesins and OMPs.717 BabA.717 SabA and OipA.718 DupA.718 FlaA.718 HOST FACTORS.718 Host Polymorphisms That Influence the Propensity toward Gastric Cancer Development.718 IL-1p .718 TNF-a.719 IL-10.719 IL-8 .719 COX-2.719 Acid Secretion.720 Oxidative Damage .721 Role of the host immune response in H. pylori-induced carcinogenesis .721 General Considerations for Innate and Adaptive Immunity.721 Innate immunity.721 Adaptive immunity.721 Immune Response to H. pylori .721 Macrophages.722 i Macrophage signaling of T cells .722 ii Macrophages as effector cells .722 iii Macrophage apoptosis.722 iv Avoidance of phagocytosis by macrophages.723 DCs .724 T cells .725 B cells .726 Inflammation-mediated migration of peripheral cells.726 Apical-Junctional Complexes .726 Tight junctions .726 Adherens junctions .728 Alterations in Cellular Turnover That Predispose Individuals to H. pylori-Induced Malignant Transformation .728 ENVIRONMENTAL FACTORS .729 Role of Salt as a Risk Factor for Gastric Adenocarcinoma .729 Helminth Infection.730 Dietary Antioxidants.730 Cigarette Smoking .730 Corresponding author. Mailing address Division of .