tailieunhanh - Porous metal organic framework nanoscale carriers as a potential platform for drug delivery and imaging

Porous metal organic framework nanoscale carriers as a potential platform for drug delivery and imaging, In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading and or rapid release of the proportion of the drug that is simply adsorbed at the external surface of the nanocarrier. In this context, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are well suited to serve as nanocarriers for delivery and imaging applications. | nature materials ARTICLES PUBLISHED ONLINE 13 DECEMBER 2009 DOI NMAT2608 Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging Patricia Horcajada1 Tamim Chalati2 Christian Serre1 Brigitte Gillet3 Catherine Sebrie3 Tarek Baati1 Jarrod F. Eubank1 Daniela Heurtaux1 Pascal Clayette4 Christine Kreuz4 Jong-San Chang5 Young Kyu Hwang5 Veronique Marsaud2 Phuong-Nhi Bories6 Luc Cynober6 Sophie Gil7 Gérard Ferey1 Patrick Couvreur2 and Ruxandra Gref2 In the domain of health one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading usually less than 5 wt of the transported drug versus the carrier material and or rapid release of the proportion of the drug that is simply adsorbed or anchored at the external surface of the nanocarrier. In this context porous hybrid solids with the ability to tune their structures and porosities for better drug interactions and high loadings are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron iii -based metal-organic frameworks with engineered cores and surfaces as well as imaging properties function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs that is busulfan azidothymidine triphosphate doxorubicin or cidofovir against cancer and AIDS. In addition to their high loadings they also potentially associate therapeutics and diagnostics thus opening the way for theranostics or personalized patient treatments. For nanocarriers the requirements for ensuring an efficient therapy are to 1 efficiently entrap drugs with high payloads 2 control the release and avoid the burst effect important release within the first minutes 3 control matrix degradation 4 offer the possibility to easily engineer its surface to control in vivo fate and 5 be detectable by imaging