tailieunhanh - Lecture Principles of biochemistry - Chapter 8 (part 2): Carbohydrates: oligo and polysaccharides

In this chapter, students will be able to: draw Fischer and Haworth projections of D-glucose, D-galactose, D-fructose, D-ribose and D-ribulose; be able to identify the anomeric carbon. Be able to write and recognize the differences between alpha- and beta- forms; know the difference between furanoses and pyranoses; be familiar with chair and boat conformations of pyranose sugars, know what makes a reducing sugar a reducing sugar,. | Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides Glycosidic Linkage Disaccharides maltose cellobiose lactose sucrose (a-D-glucosyl-(1->4)-b-D-glucopyranose) (b-D-glucosyl-(1->4)-b-D-glucopyranose) (b-D-galactosyl-(1->4)-b-D-glucopyranose) (a-D-glucosyl-(1->2)-b-D-fructofuranose) Higher Oligosaccharides Oligosaccharide groups are incorporated in to many drug structures Polysaccharides Amylose and Amylopectin Iodine binding to starch glycogen Dextrans Cellulose Cellulose vs Amylose Glucose units rotated 180o relative to next residue cellulose amylose Cellulose Chitin Chitin vs Cellulose Glycoproteins O-linked Glycoproteins Blood ABO Antigens Structure of the ABO blood group carbohydrates, R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound form open square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA) N-linked Glycoproteins | Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides Glycosidic Linkage Disaccharides maltose cellobiose lactose sucrose (a-D-glucosyl-(1->4)-b-D-glucopyranose) (b-D-glucosyl-(1->4)-b-D-glucopyranose) (b-D-galactosyl-(1->4)-b-D-glucopyranose) (a-D-glucosyl-(1->2)-b-D-fructofuranose) Higher Oligosaccharides Oligosaccharide groups are incorporated in to many drug structures Polysaccharides Amylose and Amylopectin Iodine binding to starch glycogen Dextrans Cellulose Cellulose vs Amylose Glucose units rotated 180o relative to next residue cellulose amylose Cellulose Chitin Chitin vs Cellulose Glycoproteins O-linked Glycoproteins Blood ABO Antigens Structure of the ABO blood group carbohydrates, R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound form open square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA) N-linked . | Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides Glycosidic Linkage Disaccharides maltose cellobiose lactose sucrose (a-D-glucosyl-(1->4)-b-D-glucopyranose) (b-D-glucosyl-(1->4)-b-D-glucopyranose) (b-D-galactosyl-(1->4)-b-D-glucopyranose) (a-D-glucosyl-(1->2)-b-D-fructofuranose) Higher Oligosaccharides Oligosaccharide groups are incorporated in to many drug structures Polysaccharides Amylose and Amylopectin Iodine binding to starch glycogen Dextrans Cellulose Cellulose vs Amylose Glucose units rotated 180o relative to next residue cellulose amylose Cellulose Chitin Chitin vs Cellulose Glycoproteins O-linked Glycoproteins Blood ABO Antigens Structure of the ABO blood group carbohydrates, R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound form open square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA) N-linked .