tailieunhanh - 5-O-caffeoylquinic acid and cinamic acid from Gleditschia australis Hemsl (Caesalpiniaceae)

From the methanolic extract of the leaves of Gleditschia australis Hemsl., (Caesalpiniaceae) 5-O-caffeoylquinic acid (1) and cinnamic acid (2) have been isolated. Their structures were deduced from the spectral evidence and comparison with the literature. | Journal of Chemistry Vol. 45 Special issue P. 127 -130 2007 5-O-CAFFEOyLQUINIC ACID AND CINAMIC ACID FROM GLEDITSCHIA AUSTRALIS HEMSL. CAESALPINIACEAE Received 15 October 2007 NGUYEN THI HONG VAN PHAN VAN KIEM CHAU VAN MINH NGUYEN THE DUNG Institute of Natural Products Chemistry Vietnamese Academy of Science and Technology SUMMARY From the methanolic extract of the leaves of Gleditschia australis Hemsl. Caesalpiniaceae 5-O-caffeoylquinic acid 1 and cinnamic acid 2 have been isolated. Their structures were deduced from the spectral evidence and comparison with the literature. I - INTRODUCTION Gleditschia australis Hemsl. belongs to family Caesalpiniaceae and is wildly distributed in Vietnam. The fruits are used to produce soaps shampoo medicinal drugs and local people can sell them for income. It has been used in traditional medicine for various diseases such as inflammation kidney stone and diabetes mellitus. 1 2 . The fruits contain numbers of triterpenes and flavonoids 2 . However no studies on chemical constituents and bioactivity of the leaves has been carried out. As a part of our study on this plant 3 4 we report herein the isolation and the structural elucidation of 5-O-caffeoylquinic acid 1 and cinnamic acid 2 from the leaves. II - EXPERIMENTAL 1. Plant material The leaves of G. australis Hemsl. were collected in Tam Dao Mountain Vinh Phuc province Vietnam and was identified by Dr Tran Huy Thai Institute of Ecology and Biological Resources VAST. A voucher of specimen was deposited at Institute of Natural Products Chemistry INPC VAST. 2. General experimental procedures Melting points were determined using an Electro thermal IA-9200. The IR spectra were obtained on a Hitachi 270-30 type spectrometer with KBr discs. Optical rotations were determined on a Jasco DIP-1000 KUY polarimeter. The electrospray ionization ESI mass spectra were obtained using an AGILENT 1100 LC-MSD Trap spectrometer. The 1H-NMR 500 MHz and 13C-NMR 125 MHz spectra were recorded on a .