tailieunhanh - A new derivative of furancarboxaldehyde from Chlorophytum laxum R. Br. (Athericaceae)

From the methanol extract of the leaves of Chlorophytum laxum R. Br. (Athericaceae), a new (1) and two known (2, 3) derivatives of furancarboxaldehyde, and a derivative of anthraquinone (4) were isolated by various chromatography methods. Their structures were elucidated as 5- (ethoxymethyl)-2-furancarboxaldehyde (1), 5-hydroxymethyl-2-furancarboxaldehyde (2) and cirsiumaldehyde (3) and 1,5-dihydroxy-3-hydroxymethylanthraquinone (4) by analyses of the NMR (1D-, 2D-NMR), EI-MS and ESI-MS spectra. This is the first report of 2, 3, and 4 from C. laxum. | Journal of Chemistry Vol. 45 Special issue P. 131 -135 2007 A NEW DERIVATIVE OF FURANCARBOXALDEHyDE FROM CHLQRQPHYTUM LAXUM R. BR. ATHERICACEAE Received 21 March 2007 NGUyEN THI HQAI1 PHAM THANH Ky1 CHAU VAN MINH2 PHAN VAN KIEM2 1Hanoi Institute of Pharmacy Ministry of Health institute of Natural Products Chemistry Vietnamese Academy of Science and Technology SUMMARY From the methanol extract of the leaves of Chlorophytum laxum R. Br. Athericaceae a new 1 and two known 2 3 derivatives of furancarboxaldehyde and a derivative of anthraquinone 4 were isolated by various chromatography methods. Their structures were elucidated as 5- ethoxymethyl -2-furancarboxaldehyde 1 5-hydroxymethyl-2-furancarboxaldehyde 2 and cirsiumaldehyde 3 and 1 5-dihydroxy-3-hydroxymethylanthraquinone 4 by analyses of the NMR 1D- 2D-NMR EI-MS and ESI-MS spectra. This is the first report of 2 3 and 4 from C. laxum. I - INTRODUCTION In previous paper we have reported the isolation and structural elucidation of one new and three known flavone glycosides from Chlorophytum laxum which is used in folk medicine. As a part of our work on phytochemical and bioactive components from this plant 4 we report herein the isolation and structural determination of a new 1 and two known 2 3 derivatives of furancarboxaldehyde together with a derivative of anthraquinone 4 isolated from C. laxum. II - EXPERIMENTAL 1. General experimental procedures The Electronspray Ionization ESI mass spectrum was obtained using a AGILENT 1100 LC-MSD Trap spectrometer The 1H-NMR 500 MHz and 13C-NmR 125 MHz spectra were recorded on a Bruker AM500 FT-NMR spectrometer using TMS as the internal standard. Column chromatography CC was performed on silica gel Kieselgel 60 70-230 mesh and 230 - 400 mesh Merck or YMC RP-8 resins 30 - 50 pm Fujisilisa Chemical Ltd . Thin layer chromatography TLC was performed on DC-Alufolien 60 F254 Merck or RP18 F254s Merck plates. 2. Plant material The roots of Chlorophytum laxum R. Br. .