tailieunhanh - Synthesis and characterization of copolymerspeg-poly(dmaema) and peg-poly(morema) - Part II: Polymerization of dimethylaminoethylenemethacrylate (dmaema) and morpholinoethylene methacrylate (morema) using peg-azo-initiator

In the present work, the polymerization reaction of dimethylaminoethylenemethacrylate (DMAEMA) and morpholinoethylenemathacrylate (MOREMA) initiated with PEG-azo-initiator was carried out. The copolymer products obtained were characterized by IR- and NMR spectra. It was shown that the two copolymers synthesized were of good bacterial activity against Staphylocooccus aureus. | Journal of Chemistry Vol. 43 2 P. 245 - 249 2005 SYNTHESIS AND CHARACTERIZATION OF COPOLYMERS PEG-POLY DMAEMA AND PEG-POLY MOREMA PART II - POLYMERIZATION OF DIMETHYLAMINOETHYLENE METHACRYLATE DMAEMA AND MORPHOLINOETHYLENE METHACRYLATE mOREMA using PEG-AZO-INITIATOR Received 3rd-March-2004 PHAM NGOC LAN Polymer Centre Hanoi University of Technology SUMMARY In the present work the polymerization reaction of dimethylaminoethylenemethacrylate DMAEMA and morpholinoethylenemathacrylate MOREMA initiated with PEG-azo-initiator was carried out. The copolymer products obtained were characterized by IR- and NMR spectra. It was shown that the two copolymers synthesized were of good bacterial activity against Staphylocooccus aureus. Key words Polymerization polyethylene glycol PEG PEG-azo-initiator bacterial activity. I - INTRODUCTION It was reported that crosslinked block copolymers containing PEG-unit could be prepared with macroinimers 1 - 3 obtained by end-capping the reaction of either methacryloyl chloride 4-vinylbenzyl chloride or isocyanato-ethyl methacrylate with the hydroxyl end groups of polyazoesters. These are important because PEG has a high hydrophilicity flexibility and ion absorbability. This work is dealing with the radical polymerization of DMAEMA and MOREMA using PEG-azo-initiator the synthesis of which was described in the previous work 4 . In the case of monomer DMAEMA for example the final copolymer products were both poly- DMAEMA -PEG if the disproportionation takes place and PEG-poly DMAEMA -PEG or if the polymerization is terminated with recombi-nation reaction see scheme 1 . The copolymers and their quaternized products were charac-terized by IR- and NMR spectra. The bacterial activity of the quaternization copolymers was tested. II - EXPERIMENTAL 1. Materials Benzyl bromide Fluka was used without further purification. Toluene was dried by distillation over Na. Poly ethylene oxide monomethyl ether of different molecular weights were azeotropically .