tailieunhanh - Study on chemistry of the sponge petrosia niricans living in Vietnamese sea

Batilol (1), 5,8-epidioxycholest-6-en-3-ol (2), and cholesterol (3) were isolated from chloroform extract of the sponge Petrosia nigricans collected in Vietnam. Their structures were determined on the basic of the physicochemical and spectroscopic data. This is the first report of compounds 1, 2 and 3 from this species. | Journal of Chemistry Vol. 45 Special issue P. 141 -144 2007 STUDY ON CHEMISTRY OF THE SPONGE PETROSIA NIRICANS LIVING IN VIETNAMESE SEA Received 15 October 2007 TRAN THU HUQNG1 II NGUYEN TUAN ANH1 TRAN THUQNG QUANG1 CHU NHAT HUY1 TRAN THI MINH1 CHAU VAN MINH2 PHAN VAN KIEM2 1Faculty of Chemical Technology Hanoi University of Technology institute of Natural Products Chemistry Vietnamese Academy of Science and Technology SUMMARY Batilol 1 5 8-epidioxycholest-6-en-3-ol 2 and cholesterol 3 were isolated from chloroform extract of the sponge Petrosia nigricans collected in Vietnam. Their structures were determined on the basic of the physicochemical and spectroscopic data. This is the first report of compounds 1 2 and 3 from this species. Keywords Petrosia nigricans Batilol Glycerol 1-O-octadecyl ether 5 8-Epidioxycholest-6-en-3-ol Cholesterol. I - INTRODUCTION Highly functionalized steroids featuring biogenetically unprecedented structures have been found in a vast array of marine organisms particularly sponges. It has been hypothesized that the sponge s effect chemical modification of their dietary precursors in order to produce the diverse variation in steroidal content obtained from these sources 1 . Many steroids exhibit potent pharmacological properties including cytotoxic 2 and ichthyotoxic 3 effects. As part of our current investigations on bioactive compounds from marine organisms in Vietnam we report here the isolation and structural elucidation of batilol 1 5 8-epidioxycholest-6-en-3-ol 2 and cholesterol 3 from the sponge Petrosia nigricans. II - EXPERIMENTAL 1. General experimental procedures The Electronspray Ionization ESI mass spectrum was obtained using an AGILENT 1200 LC-MSD Trap spectrometer. The 1H-NMR 500MHz and 13C-NmR 125 MHz spectra were recorded on Bruker AM500 FT-NMR spectrometer. Chemical shifts are referenced to Ỗ using tetramethylsilan TMS as an internal standard. Column chromatography CC was performed on silica gel 230 - 400 mesh .

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