tailieunhanh - Báo cáo Y học: The sodium pump Its molecular properties and mechanics of ion transport

The sodium pump (Na + /K + -ATPase; sodium- and potas-sium-activated adenosine 5¢-triphosphatase; EC ) has been under investigation formore than fourdecades. During this time, the knowledge about the structure and properties of the enzyme has increased to suchan extent that specializedgroupshave formedwithin thisfield that focuson specific aspects of the active ion transport catalyzed by this enzyme. | Eur. J. Biochem. 269 2424-2433 2002 FEBS 2002 doi MINIREVIEW The sodium pump Its molecular properties and mechanics of ion transport Georgios Scheiner-Bobis From the Institut fur Biochemie und Endokrinologie Fachbereich Veteriniirmedizin Justus-Liebig-Universitat Giessen Germany The sodium pump Na K -ATPase sodium- and potassium-activated adenosine 5 -triphosphatase EC has been under invettiaation for more thao lour deeades. During this time the knowledge about the structure and properties of the enzyme has increased to such an extent that specialized groups have formed within this field that focus on specific aspects of the active ion transport catalyzed by this enzyme. Taking this into account this review while somewhat speculative is an attempt to summarize the informa tion regarding the enzymology of the sodium pump with the hope of providing to interested readers from outside the field a concentrated overview and to readers from related fields a guide in their search for gathering specific information concerning the structure function and enzymology of this enzyme. Keywords ATPase P-type ouabain palytoxin ion transport. THE SODIUM PUMP A BRIEF RETROSPECTIVE Today there is a vast amount of information concerning ion transport through biological membranes and primary structures crystals mutants and chimeras of ion transporters. It is difficult to imagine that the impressive progress achieved thus far was originally generated by a few researchers who had the ability to observe simple phenomena connected with ion distribution to question their origin and to assemble experimental evidence in ways that did not allow any otherconclusion but that there must a mechanism that enables ions to be actively transported against their electrochemical gradients. This mechanism termed a sodium pump by Dean in 1941 originates from the observation that sodium ions within muscle fibers can exchange with radioactive sodium added to their .

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