tailieunhanh - Osteoarthritis The care and management of osteoarthritis in adults

The studies confirmed the glucose-lowering benefits of metformin in combination with all other available glucose-lowering medications. The widespread use of the previous recommendations in regard of levels of serum creatinine for reduction and discontinuing therapy was acknowledged. The complete substitution of estimated glomerular filtration rate (eGFR) for serum creatinine is not possible because of uncertainty surrounding methods of eGFR calculation in many people with Type 2 diabetes. An evidence call on the use of extended-release metformin preparations did not find that their use in unselected patients reduced GI side effects. Differences in cost, and lack of other documented benefit, led to the conclusion that these therapies should be. | NHS National Institute for Health and Clinical Excellence Issue date February 2008 Osteoarthritis The care and management of osteoarthritis in adults NICE clinical guideline 59 Developed by the National Collaborating Centre for Chronic Conditions NICE clinical guideline 59 Osteoarthritis the care and management of osteoarthritis in adults Ordering information You can download the following documents from CG059 The NICE guideline this document - all the recommendations. A quick reference guide - a summary of the recommendations for healthcare professionals. Understanding NICE guidance - information for patients and carers. The full guideline - all the recommendations details of how they were developed and reviews of the evidence they were based on. For printed copies of the quick reference guide or Understanding NICE guidance phone NICE publications on 0845 003 7783 or email publications@ and quote N1459 quick reference guide N1460 Understanding NICE guidance . NICE clinical guidelines are recommendations about the treatment and care of people with specific diseases and conditions in the NHS in England and Wales This guidance represents the view of the Institute which was arrived at after careful consideration of the evidence available. Healthcare professionals are expected to take it fully into account when exercising their clinical judgement. The guidance does not however override the individual responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient in consultation with the patient and or guardian or carer and informed by the summary of product characteristics of any drugs they are considering. National Institute for Health and Clinical Excellence MidCity Place 71 High Holborn London WC1V 6NA National Institute for Health and Clinical Excellence 2008. All rights reserved. This material may be freely reproduced for educational and not-for-profit purposes. No

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