tailieunhanh - Ebook Year book - Year book of critical care medicine 2013 (1st edition): Part 2

Part 2 book "Year book - Year book of critical care medicine 2013" presents the following contents: Sepsis/septic shock, metabolism/gastrointestinal/nutrition/hematology-oncology, neurologic - Traumatic and non traumatic, renal, trauma and overdose, ethics/socioeconomic/administrative/issues, pharmacology/sedation analgesia. | 6 Sepsis Septic Shock Prognostic Value of Incremental Lactate Elevations in Emergency Department Patients With Suspected Infection Puskarich MA Kline JA Summers RL et al Univ of Mississippi Med Ctr Jackson Carolinas Med Ctr Charlotte NC Acad Emerg Med 1 9 983-985 201 2 Objectives. Previous studies have confirmed the prognostic significance of lactate concentrations categorized into groups low intermediate high among emergency department ED patients with suspected infection. Although the relationship between lactate concentrations categorized into groups and mortality appears to be linear the relationship between lactate as a continuous measurement and mortality is uncertain. This study sought to evaluate the association between blood lactate concentrations along an incremental continuum up to a maximum value of 20 mmol L and mortality. Methods. This was a retrospective cohort analysis of adult ED patients with suspected infection from a large urban ED during 2007 2010. Inclusion criteria were suspected infection evidenced by administration of antibiotics in the ED and measurement of whole blood lactate in the ED. The primary outcome was in-hospital mortality. Logistic and polynomial regression were used to model the relationship between lactate concentration and mortality. Results. A total of 2 596 patients met inclusion criteria and were analyzed. The initial median lactate concentration was mmol L interquartile range IQR to mmol L and the overall mortality rate was . In the cohort 459 patients had initial lactate levels 4 mmol L. Mortality continued to rise across the continuum of incremental elevations from 6 for lactate mmol L up to 39 for lactate 19 20 mmol L. Polynomial regression analysis showed a strong curvilinear correlation between lactate and mortality R p . Conclusions. In ED patients with suspected infection we found a curvilinear relationship between incremental elevations in lactate concentration and mortality.

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