tailieunhanh - Ebook Pediatric critical care medicine (Volume 2: Respiratory, cardiovascular and central nervous systems - 2nd edition): Part 2

(BQ) Part 2 book "Pediatric critical care medicine (Volume 2: Respiratory, cardiovascular and central nervous systems)" includes: The cardiovascular system in critical illness and injury, the central nervous system in critical illness and injury. | Part II The Cardiovascular System in Critical Illness and Injury Applied Cardiovascular Physiology in the PICU 17 Katja M. Gist Neil Spenceley Bennett J. Sheridan Graeme MacLaren and Derek S. Wheeler Abstract Normal cellular function is critically dependent upon oxygen as evidenced by the relative complexity of the organ systems that have evolved to transport oxygen from the surrounding environment to the cells - namely the cardiac respiratory peripheral vascular and hematopoietic systems. Cells do not have the means to store oxygen and are therefore dependent upon a continuous supply that closely matches the changing metabolic needs that are necessary for normal metabolism and cellular function. If oxygen supply is not aligned with these metabolic requirements hypoxia will ensue eventually resulting in cellular injury and or death. In addition to the body s compensatory mechanisms to augment oxygen delivery to the tissues most of the management of critical illness is directed at restoring the normal balance between oxygen delivery and oxygen consumption. A thorough understanding of cardiovascular physiology particularly as it applies to the management of the critically ill child in the Pediatric Intensive Care Unit PICU is therefore of utmost importance. Keywords Hemodynamics Oxygen delivery Venous return Cardiac output Neuroendocrine stress response Shock Mean circulatory filling pressure Excitation-contraction coupling Fetal circulation . Gist DO MA MSCS Department of Pediatrics Division of Critical Care Medicine Cincinnati Children s Hospital Medical Center 3333 Burnet Ave MLC 2005 Cincinnati OH 45229 USA N. Spenceley MB ChB MRCPCH Department of Pediatric Critical Care Yorkhill Children s Hospital Dalnair Street Glasgow G3 8SJ Scotland UK e-mail nspenceley@ . Sheridan MBBS FRACP FCICM Division of Paediatric Intensive Care Department of Paediatrics The Royal Children s Hospital Melbourne VIC 3052 Australia e-mail G. .

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