tailieunhanh - Ebook Heart rate and rhythm molecular basis pharmacological modulation and clinical implications: Part 2

(BQ) Part 2 book "Heart rate and rhythm molecular basis pharmacological modulation and clinical implications" presents the following contents: Mechanisms of inherited arrhythmia, role of specific channels and transporters in arrhythmia, drugs and cardiac arrhythmia. | PartV Mechanisms of Inherited Arrhythmia Chapter 21 Intracellular Calcium Handling and Inherited Arrhythmogenic Diseases Nicola Monteforte Carlo Napolitano Raffaella Bloise and Silvia G. Priori Introduction Diseases caused by a single genetic defect are referred to as monogenic disorders. These disorders are inherited as dominant or recessive traits with different inheritance patterns autosomal dominant autosomal recessive X-linked dominant X-linked recessive matrilineal transmission . In cardiology there are two major clusters of monogenic disorders a the cardiomyopathies due to alterations in sarcomeric and in cytoskeletal proteins and b the arrhythmogenic diseases that are caused by mutations in ion channels and ion channel-controlling proteins such as the long QT syndromes LQTS the Brugada syndromes the short QT syndromes SQTS and the catecholaminergic polymorphic ventricular tachycardia CPVT . N. Monteforte and R. Bloise Molecular Cardiology Fondazione S. Maugeri IRCCS Via Salvatore Maugeri 10 10A 27100 Pavia Italy C. Napolitano Molecular Cardiology Fondazione S. Maugeri IRCCS Via Salvatore Maugeri 10 10A 27100 Pavia Italy and Cardiovascular Genetics Program Leon H. Charney Division of Cardiology New York University New York NY USA . Priori Molecular Cardiology Fondazione S. Maugeri IRCCS Via Salvatore Maugeri 10 10A 27100 Pavia Italy and Cardiovascular Genetics Program Leon H. Charney Division of Cardiology New York University New York NY USA and Department of Cardiology Universita degli Studi di Pavia Pavia Italy e-mail O. N. Tripathi et al. eds. Heart Rate and Rhythm 387 DOI 978-3-642-17575-6_21 Springer-Verlag Berlin Heidelberg .

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