tailieunhanh - Ebook Cardiovascular diseases - From molecular pharmacology to evidence-Based therapeutics: Part 2

(BQ) Part 2 book "Cardiovascular diseases - From molecular pharmacology to evidence-Based therapeutics" presents the following contents: Ischemic Heart Disease - Stable ischemic heart disease, ischemic heart disease - acute coronary syndromes, heart failure, cardiac arrhythmias, ischemic stroke. | UNIT IV ISCHEMIC HEART DISEASE STABLE ISCHEMIC HEART DISEASE 13 OVERVIEW OF ISCHEMIC HEART DISEASE STABLE ANGINA AND DRUG THERAPY INTRODUCTION Ischemic heart disease IHD is the single most common cause of death in developed nations as well as in many developing countries 1 2 . IHD is an umbrella term that encompasses a spectrum of cardiac disorders caused by myocardial ischemia. The notable examples of IHD include stable IHD SIHD with stable angina as its prototypical manifestation and acute coronary syndromes ACS among many others. This chapter provides an overview of IHD and discusses the pathophysiology of SIHD and the mechanistically based drug targeting of stable angina. Chapter 14 reviews antiangi-nal drugs that have already been discussed in previous chapters and also considers some newly approved antianginal drugs that are not covered in previous chapters. The principles and guidelines regarding the management of SIHD stable angina in clinical practice are given in Chapter 15. CLASSIFICATION EPIDEMIOLOGY AND PATHOPHYSIOLOGY Classification Definition of IHD and the International Statistical Classification of Diseases and Related Health Problems-10th Revision Classification As noted earlier the term IHD refers to a spectrum of diseases of the heart caused by decreased oxygen supply to the myocardium. The International Statistical Classification of Diseases and Related Health Problems-10th Revision ICD-10 classifies IHD into the following six categories and each category consists of multiple disease entities also in Table 1. Angina pectoris 2. Acute myocardial infarction 3. Certain current complications following acute myocardial infarction 4. Subsequent myocardial infarction 5. Other acute IHD 6. Chronic IHD including coronary artery disease CAD among others Conventional Classification of IHD ICD-10 classification of IHD is comprehensive and authoritative however it is complicated and often times causes confusion. Hence

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