tailieunhanh - Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1

The main descriptive analysis rates were calculated by using interpolated and extrapolated Census Usually Resident population data from 1996, 2001, and 2006. Rates for 2008 and 2007 (with 2007 being the transition year, on the basis of the gradual implementation of interventions) were compared with the average annual rates for 2 baseline periods (1997–2001 and 2002–2006). For the longer time-trend analysis, rates were calculated by using mid-year population estimates derived by Statistics New Zealand (20). To examine the stability of the notification system for enteric diseases during the period of interest, we compared rates for campylobacteriosis notification and hospitalization with. | Viruses 2012 4 3179-3208 doi v4113179 OPEN ACCESS viruses ISSN 1999-4915 journal viruses Review Insight into Alternative Approaches for Control of Avian Influenza in Poultry with Emphasis on Highly Pathogenic H5N1 E. M. Abdelwhab f and Hafez M. Hafez Institute of Poultry Diseases Free Berlin University Konigsweg 63 14163 Berlin Germany E-Mail hafez@. de f Present address Molecular Pathogenesis and Ecology of Influenza Viruses Laboratory Institute of Molecular Biology Federal Research Institute for Animal Health Friedrich Loeffler Institute Isles of Riems Suedufer 10 17493 Greifswald Germany Author to whom correspondence should be addressed E-Mails sayedabdelwhab@ Tel. 49-30-8386-2679 49-38-3517-1263 49-38-3517-1237 Fax 49-30-838-6267 49-38-3517-1275. Received 23 September 2012 in revised form 4 November 2012 Accepted 8 November 2012 Published 19 November 2012 Abstract Highly pathogenic avian influenza virus HPAIV of subtype H5N1 causes a devastating disease in poultry but when it accidentally infects humans it can cause death. Therefore decrease the incidence of H5N1 in humans needs to focus on prevention and control of poultry infections. Conventional control strategies in poultry based on surveillance stamping out movement restriction and enforcement of biosecurity measures did not prevent the virus spreading particularly in developing countries. Several challenges limit efficiency of the vaccines to prevent outbreaks of HPAIV H5N1 in endemic countries. Alternative and complementary approaches to reduce the current burden of H5N1 epidemics in poultry should be encouraged. The use of antiviral chemotherapy and natural compounds avian-cytokines RNA interference genetic breeding and or development of transgenic poultry warrant further evaluation as integrated intervention strategies for control of HPAIV H5N1 in poultry. Keywords influenza H5N1 control Viruses 2012 4 Abbreviations AIV avian .