tailieunhanh - Ebook Lippincott illustrated reviews flash cards biochemistry: Part 2

(BQ) Part 2 book "Lippincott illustrated reviews flash cards biochemistry" presents the following contents: Nitrogen metabolism, metabolism integration, genetic information storage and expression, blood clotting. | Answer Steroid Hormones Pregnenolone derived from cholesterol is the parent of all steroid hormones. Desmolase a CYP enzyme CYP11A or P450sal of the inner mitochondrial membrane catalyzes cholesterol hydroxylation and sidechain cleavage scc . This is the initial and rate-limiting step. ACTH or corticotropin from the pituitary gland stimulates cortisol synthesis and release. Cortisol binds to soluble receptors and the receptor-hormone complex binds as a dimer to HREs on DNA thereby altering gene expression. Changes in expression result in increased gluconeogenesis as well as weakened immune and inflammatory responses. Decreased aldosterone and cortisol production and increased androstenedione production are characteristic of 21-a-hydroxylase deficiency the most common cause of CAH. In the classic form salt wasting characterized by dehydration hypotension hyponatremia and hyperkalemia is seen because of aldosterone deficiency. With 21-a -hydroxylase deficiency masculinization of female genitalia is seen because of androgen overproduction. In contrast 17-a-hydroxylase deficiency causes femalelike genitalia in both sexes because of the absence of androgens. Lippincott Illustrated Reviews Flash Cards Biochemistry Copyright 2015 Wolters Kluwer Overall Nitrogen Metabolism Question What are the three inputs to the amino acid pool shown What is protein turnover t Compare and contrast the proteasomal and lysosomal systems of protein degradation. I What does it mean for an individual to be in N balance Positive N balance Lippincott Illustrated Reviews Flash Cards Biochemistry Copyright 2015 Wolters Kluwer Answer Overall Nitrogen Metabolism Three inputs to the amino acid pool are the 1 degradation of body protein 2 degradation of dietary protein and 3 synthesis of nonessential amino acids. Protein turnover is the ongoing synthesis and degradation of a protein. In a healthy adult the rate of synthesis is just sufficient to replace the amount of protein that was .

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