tailieunhanh - Ebook Histology text and atlas: Part 2

(BQ) Part 2 book "Histology text and atlas" presents the following contents: Bone, nervous tissue, muscle tissue, circulatory system, lymphoid (immune) system, oral cavity, gastrointestinal tract, accessory glands of the gastrointestinal tract, respiratory system, urinary system, male reproductive system,. | Chapter 7 Bone 83 Formation of Primary Centre of Ossification Osteoprogenitor cells o perichondrium orm periosteal bud which consists o blood capillaries osteoprogenitor cells and osteoclasts Fig. . T e periosteal bud excavates through the bone collar and erodes the wall o primary areolae the primary areolae use and orm larger spaces known as secondary areolae Fig. . T e space gets flled with primitive bone marrow cells. Osteoblasts orm osteoid on the sur ace o the calcifed cartilage matrix and the osteoid gets calci-f ed orming trabeculae o spongy bone. Later the calcif ed cartilage matrix present in the core o the trabeculae is removed by osteoclasts giving rise to mature trabeculae o the spongy bone. T e central part o the cartilage model where these changes occur is now called the primary centre of ossif cation Fig. . Similar processes occur in the cartilage close to the sha t resulting in ormation o bone towards the epiphysis. Secondary Centres of Ossification A ter birth new centres o ossif cation secondary ossif cation centres appear in the ends o long bones Fig. . T e cartilage o the epiphyses undergoes the same sequence o events as in the diaphysis. In the secondary centre the cartilage growth and subsequent ossif cation spreads out in all directions Fig. . Entire cartilage is replaced by bone except in two regions at the ree end which remains as articular cartilage and between the epiphysis and the diaphysis orming the epiphyseal plate or epiphyseal cartilage. a Perichondrium Mature Calcified matrix chondrocytes surrounding the mature chondrocyte s b Figure Steps of endochondral ossifcation. a Longitudinal section of a growing hyaline cartilage. b As cartilage increases in size chondrocytes mature and enlarge towards the centre of the shaft. continued 84 Histology Text and Atlas Periosteum Periosteal bone collar Primary areolae Calcified matrix c Newly added cartilage Newly added cartilage New primary areolae Blood .

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