tailieunhanh - Ebook Textbook of organic medicinal and pharmaceutical chemistry (12 edition): Part 2

(BQ) Part 2 book "Textbook of organic medicinal and pharmaceutical chemistry" presents the following contents: Centralnervous system depressants, central dopaminergic signaling agents, anticonvulsants, central nervous system stimulants, adrenergic agents, drugs acting on the renal system,. | Dr. Murtadha Alshareifi e-Library CHAPTER 12 Central Nervous System Depressants SHENGQUAN LIU Although the brain is undoubtedly the most wondrously complex organ it is possible to distil the way it works into two opposing forces excitation and inhibition depressing . Central nervous system CNS depressants are drugs that can be used to slow down or depress the functions of the CNS. Although many agents have the capacity to depress the function of the CNS CNS depressants discussed in this chapter include only anxiolytics sedative-hypnotics and antipsychotics. There is some overlap between the first two groups. They often have several structural features in common and likewise often share at least one mode of action positive modulation of the action of y-aminobutyric acid GABA at GABAA receptor complex. The list of anxiolytic sedative and hypnotic drugs is a short one benzodiazepines Z-drugs barbiturates and a miscellaneous group. Antipsychotic drugs previously known as neuroleptic drugs antischizophrenic drugs or major tranquilizers are used in the symptomatic treatment of thought disorders psychoses most notably the schizophrenias. Antipsychotics are grouped into typical and atypical categories. Both categories share a common feature a dopamine DA -like structure often hydrophobically substituted. This feature can be related to the most commonly cited action of these agents competitive antagonism of DA at D2 or occasionally D3 or D4 receptors in the limbic system. The fundamental differences between typical and atypical antipsychotics are that the atypical agents are a less prone to produce extrapyramidal symptoms EPS because they are less able to block striata D2 receptors vis-à-vis limbic D2 and D3 receptors and b more active against negative symptoms social withdrawal apathy anhedonia . o ANXIOLYTIC SEDATIVE AND HYPNOTIC AGENTS In addition to benzodiazepines barbiturates and a miscellaneous group many drugs belonging to other pharmacological classes may possess .

• Y khoa - Dược
• Textbook of organic medicinal
• Pharmaceutical chemistry
• Centralnervous system depressants
• Central dopaminergic signaling agents
• Adrenergic agents
• Drugs acting on the renal system
• Board review series Pharmacology
• Current drug information
• Drugs acting on the central nervous system
• Immunosuppressive agents